The CVS Pharmacy 856 Ship Notice / ASN, explained

What CVS Pharmacy expects in the 856

CVS Pharmacy trades on X12 4010 over AS2. Beyond the base standard, watch these:

How EDISQ maps it

The certified CVS Pharmacy 856 map loads when you enable the partner — fields auto-map from NetSuite, QuickBooks, Dynamics, and 33 other systems, validation runs against CVS Pharmacy's spec before transmission, and the sandbox replays CVS Pharmacy test scenarios until everything passes.

Common rejection reasons

Nearly all 856 rejections trace to reference data, not syntax: identifiers that don't match CVS Pharmacy's cross-references, echoed fields dropped from the original PO, or timing that misses the program window. EDISQ flags each before CVS Pharmacy ever sees the document.

Sample CVS Pharmacy 856

A representative 856 interchange addressed to CVS Pharmacy — envelope, shipment→order→pack→item hierarchy, and control totals:

1ISA*00*          *00*          *ZZ*ACMESUPPLY     *ZZ*CVS            *260101*1200*U*00401*000000001*0*P*>~
2GS*SH*ACMESUPPLY*CVS*20260101*1200*1*X*004010~
3ST*856*0001~
4BSN*00*SHIP0001*20260101*1200*0001~
5HL*1**S~
6TD1*CTN25*3****G*180*LB~
7TD5*B*2*UPSN*M~
8REF*BM*BOL000123~
9DTM*011*20260105~
10N1*ST*CVS PHARMACY DC 5093*92*5093~
11HL*2*1*O~
12PRF*PO12345~
13HL*3*2*P~
14MAN*GM*00000123450000000017~
15HL*4*3*I~
16LIN**UP*012345678905~
17SN1**24*EA~
18CTT*4~
19SE*17*0001~
20GE*1*1~
21IEA*1*000000001~

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