Cardinal Health · EDI 855

The Cardinal Health 855 Purchase Order Acknowledgment, explained

What Cardinal Health expects in the 855 — confirms what you can ship against the PO — quantities, dates, substitutions — and how EDISQ's certified map handles it from your ERP.

Connect to Cardinal Health free 855 glossary guide

What Cardinal Health expects in the 855

Cardinal Health trades on X12 4010 over AS2. Beyond the base standard, watch these:

Line statusevery PO1 gets an answer — accepted, substituted, or backordered; blanket header-level acknowledgments bounce
Substitutionsa substituted line must cite the replacement NDC, not just a free-text note

How EDISQ maps it

The certified Cardinal Health 855 map loads when you enable the partner — fields auto-map from NetSuite, QuickBooks, Dynamics, and 33 other systems, validation runs against Cardinal Health's spec before transmission, and the sandbox replays Cardinal Health test scenarios until everything passes.

Common rejection reasons

Nearly all 855 rejections trace to reference data, not syntax: identifiers that don't match Cardinal Health's cross-references, echoed fields dropped from the original PO, or timing that misses the program window. EDISQ flags each before Cardinal Health ever sees the document.

Sample Cardinal Health 855

A representative 855 interchange addressed to Cardinal Health — envelope, body segments, and control totals:

1ISA*00*          *00*          *ZZ*ACMESUPPLY     *ZZ*CARDINALHEALTH *260101*1200*U*00401*000000001*0*P*>~
2GS*PR*ACMESUPPLY*CARDINALHEALTH*20260101*1200*1*X*004010~
3ST*855*0001~
4BAK*00*AC*PO12345*20260101~
5PO1*1*24*EA*9.75**UP*012345678905~
6ACK*IA*24*EA~
7PO1*2*12*EA*14.50**UP*012345678912~
8ACK*IA*12*EA~
9CTT*2~
10SE*8*0001~
11GE*1*1~
12IEA*1*000000001~

FAQ

Which 855 version does Cardinal Health use?

X12 4010, delivered over AS2. The certified map tracks Cardinal Health's current companion guide.

How do I test a Cardinal Health 855?

The sandbox generates realistic Cardinal Health 855 scenarios against your live mapping — free, unlimited, invisible to Cardinal Health.

What does it cost?

Per document only: first 25/month free, then from $0.50, decreasing with volume. No partner or mapping fees.